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. 2018 May 1;11(5):2408–2418.

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IJCEP Copyright © 2018

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The relationship between the frequency of TIGIT-expressing natural killer (NK) cells, NK-cell phenotype, and cytokine secretion. A. There was significantly decreased expression of activation markers CD69 on TIGIT⁺ NK cells from patients with systemic lupus erythematosus (SLE) compared with that in TIGIT^- NK cells in patients with SLE. B. The percentage of CD69⁺ NK cells was significantly inversely correlated with the percentage of TIGIT⁺ NK cells among patients with SLE. C. There was a significantly decreased expression of CD107a on TIGIT⁺ NK cells from patients with SLE compared with that in TIGIT^- NK cells in patients with SLE. D. No obvious correlation was observed between the percentage of CD107a⁺ NK cells and the percentage of TIGIT-expressing NK cells in SLE patients. E. The production of IFN-γ in TIGIT^- NK cells was significantly higher than that in TIGIT⁺ NK cells in patients with SLE. F. The percentage of TIGIT⁺ NK cells was significantly inversely correlated with their IFN-γ-producing capacity in patients with SLE. G. The functional anti-TIGIT monoclonal antibody could increase the IL-12-stimulated IFN-γ production by high level TIGIT expression NK cells in SLE patients.