Table 4.
Biodistribution of [55Co]Co-rf42 in KB tumor bearing mice a.
| Organ | 4 h | 4 h Blocking b | 24 h |
|---|---|---|---|
| Blood | 8 ± 3 | 15 ± 2 | 1.0 ± 0.4 |
| Heart | 2.9 ± 0.4 | 4 ± 1 | 2.0 ± 0.4 |
| Lungs | 4 ± 1 | 5.6 ± 0.3 | 1.5 ± 0.4 |
| Pancreas | 2.4 ± 0.5 | 2.2 ± 0.2 | 1.9 ± 0.3 |
| Spleen | 1.5 ± 0.3 | 2.1 ± 0.3 | 0.6 ± 0.2 |
| Stomach | 0.8 ± 0.4 | 1.1 ± 0.5 | 0.5 ± 0.2 |
| Liver | 3.8 ± 0.6 | 4 ± 1 | 2.9 ± 0.5 |
| Kidney | 53 ± 12 | 12 ± 4 | 46 ± 14 |
| Intestine | 2.2 ± 0.5 | 2.2 ± 0.3 | 0.8 ± 0.2 |
| Fat | 3.2 ± 0.9 | 2.7 ± 0.6 | 2.7 ± 0.2 |
| Skin | 8 ± 1 | 3.5 ± 0.8 | 6 ± 2 |
| Muscle | 1.6 ± 0.4 | 1.5 ± 0.3 | 1.2 ± 0.6 |
| Bone | 1.3 ± 0.2 | 1.7 ± 0.5 | 0.6 ± 0.2 |
| Brain | 0.7 ± 0.1 | 0.5 ± 0.1 | 0.4 ± 0.1 |
| Tumor | 17 ± 4 | 7 ± 2 | 15 ± 6 |
a Values reported as % IA/g ± SD, n = 4; b Co-administration of a 100 µg folic acid blocking dose.