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Mechanism of drug release from thermosensitive liposomes. (A) Schematic illustration of the mechanism of phase transition of the lipids that form the liposome bilayer. The increase of the temperature above the transition phase temperature (47 °C) leads to higher bilayer permeability, and consequently, the drug release is favored. (B) Amphiphilic molecules forming lamellar structures and their transition phase temperatures. Tc: Phase transition temperature.
