Table 2.
Recent preclinical studies using hyperthermia and thermosensitive micelles.
| Thermosensitive Micelles | |||||
|---|---|---|---|---|---|
| Composition | HT | Drug | Target | Response | Ref. |
| Poly(N-isopropylacrylamide-co-acrylamide)-b-poly(DL-lactide) | Water bath | Docetaxel | Lung cancer | Higher antitumor efficacy in mice treated with docetaxel-loaded micelles accompanied by hyperthermia | [76] |
| Poly(N-isopropylacrylamide-co-acrylamide)-b-poly(DL-lactide) | Water bath | Docetaxel and Paclitaxel | Gastric Cancer | Weight growth percentage inhibition of more than 80% | [77] |
| P(FAA-NIPA-co-AAm-co-ODA) and P(FPA-NIPA-co-AAm-co-ODA) | Water bath | Paclitaxel | Lung cancer | Increased accumulation of paclitaxel at tumor sites, local drug concentration was greatly enhanced | [75] |
HT: Hyperthermia; P(FAA-NIPA-co-AAm-co-ODA): Poly(folate acrylic acid-N-Isopropylacrylamide-co-octadecyl acrylate); P(FPA-NIPA-co-AAm-co-ODA): Poly(folate-PEG acrylic acid-N-Isopropylacrylamide-co-octadecyl acrylate).