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. 2019 Oct 23;12(4):160. doi: 10.3390/ph12040160

Table 1.

Protonation and acidity constants of 1 and 2.

1 2
pKa1 2.39 (4) 1 2.21 (5)
pKa2 3.66 (4) 2.82 (3)
pKa3 6.99 (6) 3.72 (8)
pKa4 8.67 (8) 7.17 (2)
pKa5 - 11.09 (1)
pKa6 - 11.79 (2)

1 The calculated uncertainties for logβm1h were determined on the basis of the standard deviation. Values in parentheses refer to estimated standard deviations for the last significant digit. I = 0.1 mol.L−1 (KCl); T = 298 K, H2O/DMSO media (v/v 50:50).