Table 2.
Calculated IC50 values for the two main repositionable compounds miltefosine and iodoquinol against different C. auris strains from the CDC panel, under the three different growing conditions: inhibition of planktonic growth, inhibition of biofilm formation, and activity against preformed biofilms. Values are in μg/mL.
| C. auris Strain | IC50 of Inhibition of Planktonic Growth | IC50 of Inhibition of Biofilm Formation | IC50 of Reduction of Pre-Formed Biofilms | |||
|---|---|---|---|---|---|---|
| Miltefosine | Iodoquinol | Miltefosine | Iodoquinol | Miltefosine | Iodoquinol | |
| 0381 | 0.9237 | 0.7959 | 1.158 | 24.47 | 9.144 | >64 |
| 0382 | 2.472 | 0.4489 | 4.988 | 27.79 | 14.69 | >64 |
| 0383 | 1.379 | 1.571 | 1.702 | 52.12 | 9.449 | >64 |
| 0384 | 1.404 | 2.006 | 2.645 | 56.02 | 9.214 | >64 |
| 0385 | 2.149 | 1.565 | 4.656 | 33.60 | 14.84 | 38.58 |
| 0386 | 2.152 | 0.8520 | 4.538 | 25.88 | 14.59 | 49.11 |
| 0387 | 2.265 | 0.7733 | 5.160 | 14.50 | 13.91 | >64 |
| 0388 | 2.129 | 0.4545 | 5.374 | 25.37 | 20.98 | >64 |
| 0389 | 2.139 | 0.6701 | 6.049 | 9.159 | 13.62 | >64 |
| 0390 | 1.984 | 0.2972 | 3.932 | 43.40 | 13.91 | >64 |