Table 1.

Imaging data of the antidepressant placebo response, captured in clinical trials primarily focused on antidepressant efficacy or predicting antidepressant response.

Reference	N	Method	Brain Regions Associated with Antidepressant Placebo Response
[15]	17	FDG PET after 1 and 6 wks PBO or ADT	rACC, pACC, NAc, OFC, dlPFC, PMC, IPC, Hyp, Tha, SSA, pIns, pHipp; also predict ADT response.
[16,17]	51	EEG at baseline, after 1 week single-blind PBO lead-in, and 2, 4, 6, and 8 wks ADT	Frontocentral cortex
[18]	72	EEG at baseline	None
[19]	144	EEG at baseline, after 1 week PBO	rACC;
[20]	248	EEG at baseline, after 1 week PBO or ADT	rACC; also predicts ADT response
[21]	238	EEG at baseline, after 1 week PBO or ADT, functional connectivity analysis.	rACC, rAI; also predicts ADT response

Key: FDG = fluorodeoxyglucose; PET = positron emission tomography; PBO = placebo; ADT = antidepressant treatment; EEG = electroencephalogram; PFC = prefrontal cortex; PMC = premotor cortex; IPC = inferior parietal cortex; pIns = posterior insula; pACC = posterior anterior cingulate cortex; sgACC = subgenual anterior cingulate cortex; rACC = rostral anterior cingulate cortex; Hyp = hypothalamus; Tha = thalamus; SSA = supplementary sensory area; pHipp = parahippocampus.