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. 2019 Dec 10;12(4):181. doi: 10.3390/ph12040181

Figure 2.

Figure 2

YAP1 mRNA expression in multiple PCa clinical cohorts. YAP1 mRNA data were analyzed from The Cancer Genome Atlas (TCGA) datasets through UALCAN and the c-Bioportal web server. (A) mRNA level of YAP1 was significantly decreased in primary prostate tumors as compared to normal prostate tissues. (B) A decrease in YAP1 mRNA levels was observed in patients with a higher Gleason score (TCGA datasets) as compared to normal controls. (C) YAP1 mRNA levels were significantly decreased in PCa patients irrespective of lymph node metastasis as compared to normal controls (TCGA datasets). (D) 51% of patients showed a genetic alteration in YAP1 mRNA levels in the Prostate Adenocarcinoma MSKCC dataset. [31] (E) Representative images is from The Human Protein Atlas showed a decreased level of YAP1 protein in high-grade PCa tumor samples as compared to low-grade PCa tumor samples.