Table 4.
Associations of clinical characteristics with time to lost to follow-up among patients registered in a comprehensive sickle cell disease program led by an NGO in a tribal area of Gujarat, India during December 2015–June 2017; N = 112.
| Characteristics | Categories | Person-years | LTFU number | LTFU per 100 person-years | Unadjusted HR * (95% CI) | Adjusted HR * (95% CI) |
|---|---|---|---|---|---|---|
| Hospitalized at registration | Yes | 403.8 | 71 | 31.6 | 1.7 (1.1–2.5) | 1.7 (1.1–2.6) |
| No | 129.6 | 41 | 17.6 | 1 | 1 | |
| Number of pain crisis episodes in the last year | 0 | 75.9 | 6 | 7.9 | 1 | 1 |
| 1 | 86.9 | 23 | 26.5 | 3.1 (1.3–7.6) | 3.0 (1.2–7.5) | |
| 2 | 113.8 | 33 | 28.9 | 3.2 (1.4–7.7) | 3.6 (1.5–8.8) | |
| >=3 | 256.7 | 50 | 19.5 | 2.1 (0.9–5.0) | 2.4 (1.0–5.7) | |
| Number of hospitalizations in the last year | 0 | 349.5 | 72 | 20.6 | 1 | 1 |
| 1 | 115.3 | 24 | 20.8 | 1.1(0.7–1.7) | - | |
| 2 | 40.9 | 11 | 26.9 | 1.4 (0.8–2.7) | - | |
| >=3 | 27.8 | 5 | 18.0 | 1.0 (0.4–2.4) | - | |
| Number of blood transfusions in the last year | 0 | 423.9 | 91 | 21.4 | 1 | 1 |
| 1 | 54.2 | 16 | 29.5 | 1.48 (0.9–2.5) | 1.2 (0.7–2.1) | |
| >=2 | 55.3 | 5 | 0.90 | 0.5 (0.2–1.2) | 0.3 (0.1–0.8) | |
| Severe anemia | Yes | 70.4 | 98 | 19.9 | 0.9 (0.5–1.6) | - |
| No | 463.0 | 14 | 21.2 | 1 | ||
| Presence of sickle cell complications | Yes | 22.2 | 7 | 31.5 | 1.6 (0.8–3.5) | 1.1 (0.5–2.6) |
| No | 511.2 | 105 | 20.5 | 1 | 1 |
* Hazard ratio.