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Heme biosynthesis. 5-aminolevulinic acid (5-ALA) resulting from the condensation of succynil-CoA and glycine. It can pass through the mitochondrial membrane. Once inside the cytosol after different enzymatic reactions it is converted into coproporphyrinogen III, which in turn re-enters the inner mitochondrial membrane. Then, after two consecutive reactions it is transformed into heme. This heme group works functions as a negative feedback for the 5-ALA synthesis.
