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A summary of miR-205-5p expression regulation and direct targets of miR-205-5p and their biological effects. Overexpression of ERBB2 promotes methylation of the miR-205-5p promoter via the Ras/Raf/MEK/ERK pathway which upregulates DNMTs, which finally results in miR-205-5p downregulation. TP53 and HES also inhibit miR-205-5p expression. MiR-205-5p targets different genes directly to regulate cell proliferation, tumor metastasis, stemness, and therapeutic resistance.
