Figure 3.

KP1019 incorporation into polylactic acid nanoparticles (PLA NPs): (a) chemical structures of polylactic acid and of the surfactant used in the formulation (poloxamer Pluronic F-68 and polysorbate Tween 80); (b) nanoparticle appearance after different temperature and period storage: TWNP_3 (5 d, 4 °C), TWNP_2 (24 h, 4 °C), TWNP_4 (24 h, 25 °C), TWNP_1 (2 h, 25 °C), blank TWNP, from left to right; (c) IC₅₀ values (µM) of the different KP1019 nanoformulations prepared in comparison with naked KP1019. Blank TWNP_1 (1 month, 4 °C), Blank TWNP_2 (2 h, 25 °C); IC₅₀ values are reported as mean ± SEM. (d) dose-response curves of colon carcinoma SW480 and the hepatoma Hep3B cancer cell lines with the indicated drugs as determined by MTT assay after 72 h treatment. Figures were adapted from [111] published by The Royal Society of Chemistry.