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. 2019 Sep 26;12(4):146. doi: 10.3390/ph12040146

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(a) Chemical structures of mononuclear and dinuclear Ru(III)-dithiocarbamato complexes and of the investigated dithiocarbamato ligands: pyrrolidyl dithiocarbamate (PDT) and carbazolyl dithiocarbamate (CDT); (b) schematic representation of the Pluronic^® F127 block copolymer and micelle formation with Ru(III) complex internalization; (c) IC₅₀ values (μM) evaluated after 72 h treatment with free Ru(III)-dithiocarbamato complexes and their micelles formulations (indicated as PL{compound}). IC₅₀ values are reported as mean ± SEM. Figures are adapted from [117].