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. Author manuscript; available in PMC: 2020 Dec 23.

Published in final edited form as: J Control Release. 2019 Dec 24;319:157–167. doi: 10.1016/j.jconrel.2019.12.038

Figure 2. — FRET intensity is stable following dilution of (A) mPEG_2.2k-CL_3.1k and (B) mPEG_5.4k-LA_28.5k micelles in 10% biological fluid compared to (C) mPEG_2k-LA_2.7k micelles. Micelles exhibit changes in FRET when diluted to 200x the CMC in phosphate buffered saline (PBS; ) or biologic fluids (10%): human cerebrospinal fluid (CSF; ■), human ascites fluid (AF; ▲), human serum (HS; ●), fetal bovine serum (FBS; ◆), human pleural fluid (PF; ▼), and human synovial fluid (SF; ). Points represent the mean plus or minus (±) the standard error of the mean of three independent experiments.

Inline graphic — FRET intensity is stable following dilution of (A) mPEG_2.2k-CL_3.1k and (B) mPEG_5.4k-LA_28.5k micelles in 10% biological fluid compared to (C) mPEG_2k-LA_2.7k micelles. Micelles exhibit changes in FRET when diluted to 200x the CMC in phosphate buffered saline (PBS; ) or biologic fluids (10%): human cerebrospinal fluid (CSF; ■), human ascites fluid (AF; ▲), human serum (HS; ●), fetal bovine serum (FBS; ◆), human pleural fluid (PF; ▼), and human synovial fluid (SF; ). Points represent the mean plus or minus (±) the standard error of the mean of three independent experiments.