Fig. 1.

X-ray images of pediatric patients with hypophosphatasia (HPP). (A) Bone X-ray image of perinatal lethal HPP. Marked hypomineralization of all bones in the body, including the cranium, vertebrae, and long bones, and deformation of long bones are observed. Rickets-like metaphyseal irregularity is noted. The thorax is small, and respiratory disorder is inevitable. (B) Bone X-ray image of perinatal benign HPP. Hypomineralization is very minimal, and no metaphyseal irregularity is noted. Long bones are deformed. Bone spurs are noted sporadically.