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. 2020 Jan 13;37(1):85–103.e9. doi: 10.1016/j.ccell.2019.12.003

Figure 2.

Figure 2

ROCK-Myosin II Pathway Is Transcriptionally Rewired during Development of Resistance

(A) Cell lines used for gene expression (Obenauf et al., 2015, Song et al., 2017).

(B) Heatmap of unsupervised hierarchical clustering of 313 cytoskeleton-related genes in A375 48 h BRAFi (Obenauf et al., 2015); M229-, M238-, SKMEL28-, M395p2-, M395p1-, and M249-derivatives (Song et al., 2017). Fold change expression in resistant versus parental lines is shown.

(C) Percentage of upregulated/downregulated (1.5-fold) cytoskeleton-genes versus parental line.

(D) Percentage of upregulated genes. Boxplot: median (center line); interquartile range (box); min-max (whiskers). p value by unpaired t test with Welch's correction, ∗∗∗∗p < 0.0001.

(E) Left, schematic pathway. Right, percentage of group 1 cell lines with upregulation of indicated genes.

See also Table S3.