Table 2.
Probe | Chr: position | Gene | Region | MRS | Army STARRS | Stage 1: MRS and Army STARRS | Stage 1: replication in PRISMO | Stage 2: meta-analysis of 3 cohorts | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
β | SE | p value | β | SE | p value | Z | p value | β | SE | p value | Z | p value | ||||
cg05656210 | 5: 141660565 | Intergenic | Intergenic | − 0.37 | 0.15 | 1.6E−02 | − 0.58 | 0.09 | 6.1E−10 | − 5.73 | 1.0E−08 | − 0.47 | 0.20 | 2.0E−02* | − 6.14 | 8.1E−10 |
cg12169700 | 7: 1923695 | MAD1L1 | Body | − 1.24 | 0.27 | 4.2E−06 | − 0.19 | 0.20 | 3.3E−01 | − 4.22 | 2.4E−05 | − 0.64 | 0.14 | 4.3E−06 | − 5.91 | 3.3E−09 |
cg20756026 | 17: 80394529 | HEXDC | Body | − 0.62 | 0.21 | 3.3E−03 | − 0.28 | 0.09 | 2.6E−03 | − 4.17 | 3.0E−05 | − 0.37 | 0.09 | 2.6E−05 | − 5.69 | 1.3E−08 |
cg16956686 | 7: 4304779 | SDK1 | Body | − 0.19 | 0.04 | 3.6E−07 | − 0.13 | 0.05 | 7.1E−03 | − 5.67 | 1.5E−08 | − 0.04 | 0.09 | 6.3E−01 | − 5.20 | 2.0E−07 |
cg18917957 | 1: 15764093 | CTRC | TSS1500 | − 0.34 | 0.08 | 2.3E−05 | − 0.26 | 0.08 | 4.9E−04 | − 5.48 | 4.2E−08 | − 0.06 | 0.13 | 6.4E−01 | − 5.03 | 5.0E−07 |
cg05901543 | 16: 89251975 | CDH15 | Body | − 0.14 | 0.03 | 2.4E−08 | − 0.06 | 0.03 | 7.1E−02 | − 5.50 | 3.7E−08 | 0.01 | 0.05 | 8.2E−01 | − 4.71 | 2.5E−06 |
SE standard error. All positions and regions were in reference to GRCh37/hg19. Significance (p < 1.13 × 10−7) is indicated in italics. The asterisk indicates significance of replication after the Bonferroni correction for four probes (one-sided z test). The p values for MRS, Army STARRS, and the combined analyses are Bonferroni-corrected for ~ 450K CpG sites. In stage 1, MRS and Army STARRS were combined and PRISMO was used to replicate significant findings. In stage 2, all three studies were combined. The table is organized based on significances of the DMPs in the stage 2 meta-analysis