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. 2020 Jan 13;12:11. doi: 10.1186/s13148-019-0798-7

Table 2.

Differentially methylated positions (DMPs) in MRS, Army STARRS, and PRISMO

Probe Chr: position Gene Region MRS Army STARRS Stage 1: MRS and Army STARRS Stage 1: replication in PRISMO Stage 2: meta-analysis of 3 cohorts
β SE p value β SE p value Z p value β SE p value Z p value
cg05656210 5: 141660565 Intergenic Intergenic − 0.37 0.15 1.6E−02 − 0.58 0.09 6.1E−10 − 5.73 1.0E−08 − 0.47 0.20 2.0E−02* − 6.14 8.1E−10
cg12169700 7: 1923695 MAD1L1 Body − 1.24 0.27 4.2E−06 − 0.19 0.20 3.3E−01 − 4.22 2.4E−05 − 0.64 0.14 4.3E−06 − 5.91 3.3E−09
cg20756026 17: 80394529 HEXDC Body − 0.62 0.21 3.3E−03 − 0.28 0.09 2.6E−03 − 4.17 3.0E−05 − 0.37 0.09 2.6E−05 − 5.69 1.3E−08
cg16956686 7: 4304779 SDK1 Body − 0.19 0.04 3.6E−07 − 0.13 0.05 7.1E−03 − 5.67 1.5E−08 − 0.04 0.09 6.3E−01 − 5.20 2.0E−07
cg18917957 1: 15764093 CTRC TSS1500 − 0.34 0.08 2.3E−05 − 0.26 0.08 4.9E−04 − 5.48 4.2E−08 − 0.06 0.13 6.4E−01 − 5.03 5.0E−07
cg05901543 16: 89251975 CDH15 Body − 0.14 0.03 2.4E−08 − 0.06 0.03 7.1E−02 − 5.50 3.7E−08 0.01 0.05 8.2E−01 − 4.71 2.5E−06

SE standard error. All positions and regions were in reference to GRCh37/hg19. Significance (p < 1.13 × 10−7) is indicated in italics. The asterisk indicates significance of replication after the Bonferroni correction for four probes (one-sided z test). The p values for MRS, Army STARRS, and the combined analyses are Bonferroni-corrected for ~ 450K CpG sites. In stage 1, MRS and Army STARRS were combined and PRISMO was used to replicate significant findings. In stage 2, all three studies were combined. The table is organized based on significances of the DMPs in the stage 2 meta-analysis