Table 2:

Multivariable regression analysis of SIRT1 DNA methylation level (total tissue samples)

Variables	B	Standard error	Beta	t	p value
Analysis I
Age	0.102	0.123	0.076	0.833	1.000
Sex (male 1, female 2)	0.456	4.057	0.011	0.112	1.000
BQ chewers OSCC vs healthy controls	31.497	3.939	0.782	7.997	0.000
Analysis II
Age	0.081	0.114	0.098	0.708	1.000
Sex	2.474	3.536	0.094	0.700	1.000
BQ non-chewers OSCC vs healthy controls	5.391	1.774	0.419	3.039	0.012
Analysis III
Age	0.066	0.151	0.053	0.435	1.000
Sex	2.619	4.783	0.072	0.548	1.000
BQ chewers OSCC vs BQ non-chewers OSCC	21.005	4.806	0.587	4.370	0.000

Values in italics represent statistical significance (p < 0.05); p value is calculated using Bonferroni adjustment

B unstandardized coefficients, Beta standardized coefficients, BQ betel quid, OSCC oral squamous cell carcinoma