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. 2020 Jan 13;21:26. doi: 10.1186/s12891-019-3025-y

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — CASC2 can directly interact with miR-93-5p. The interaction between CASC2 and miR-93-5p was predicted using an online RNA interaction program named IntaRNA (http://rna.informatik.uni-freiburg.de/IntaRNA/Input.jsp). It was observed that CASC2 and miR-93-5p can form strong base pairing (A). Dual luciferase reporter assay was performed by transfecting CASC2 vector and miRNA NC or CASC2 vector and miR-93-5p mimic into chondrocytes. Relative luciferase activity was compared by unpaired t test. Experiments were repeated 3 times and mean values were presented.*, p < 0.05