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. 2020 Jan 13;20:20. doi: 10.1186/s12935-020-1101-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Knockdown of EphA5 promoted the proliferation, migration, and invasion of ESCC cells in vitro. a Western blotting and qRT-PCR results showed that EphA5 expression in KYSE150 and KYSE450 cells was downregulated by siRNA treatment. b The proliferation rate of the si-EphA5 groups was higher than that of the NC groups in KYSE150 and KYSE450 cells. c The colonies formed by cells treated with si-EphA5 was more than that of NC groups in KYSE150 and KYSE450 cells. d EphA5 knockdown significantly promoted the invasion of KYSE150 and KYSE450 cells compared with the NC groups. e Wound-healing assay showed knockdown of EphA5 enhanced cell migration in KYSE150 at 12 h and KYSE450 cells at 48 h. *P < 0.05, **P < 0.01, ***P < 0.001 versus NC group