Table 1.

Grading of CNS findings in MIE[9]

Grade	Severity	Extent of involvement of brain
Grade 1	Minimal	Symmetric involvement of one lobe (frontal, temporal, parietal, or occipital) without the involvement of the corpus callosum, basal ganglia, thalami, or internal capsules
Grade 2	Mild	Symmetric involvement of two lobes, or of one lobe plus symmetric involvement of one of the corpus callosum, basal ganglia, thalami, or internal capsules
Grade 3	Moderate	Symmetric involvement of two lobes plus symmetric involvement of one of the corpus callosum, basal ganglia, thalami, or internal capsules
Grade 4	Severe	symmetric extensive, and confluent involvement of three or all lobes from the ventricular margin to the subcortical white matter, or of two lobes plus symmetric involvement of two of the following: corpus callosum, basal ganglia, thalami, or internal capsules