Table 1.
Clinical data on prostatic cancer patients with CNS metastases
| Case No. |
Site | Years after diagnosis presenting with CNS metastases |
Bony metastases |
Castrate- resistant at time of dural/brain metastasis |
Prior treatment |
|---|---|---|---|---|---|
| 1 | C6-T1 (Dural) | 3 | Yes | Yes | Hormonal/unknown |
| 2 | Cerebellum (Dural) | unknown | Unknown | Yes | Unknown |
| 3 | Frontal Lobe (Dural) | 14 | Yes | Yes | Hormonal and cytotoxic |
| 4 | Parieto-occipital (Dural) | 3 | Yes | Yes | Hormonal |
| 5 | L4 (Dural) | 10 | Yes | Yes | Hormonal, cytotoxic and immunotherapy |
| 6 | Cerebellum (Dural) | 4 | Yes | Yes | Hormonal and cytotoxic |
| 7 | T-spine (Dural) | unknown | Yes | Yes | Unknown |
| 8 | C7 (Dural) | 9 | Yes | Yes | Hormonal and cytotoxic |
| 9 | Occipital (Parenchymal) | 3 | Yes | Yes | Hormonal, cytotoxic and immunotherapy |
| 10 | Thalamus (Parenchymal) | 12 | Yes | Yes | Hormonal and cytotoxic |
| 11 | Temporal (Parenchymal) | 2 | Yes | Yes | Hormonal and cytotoxic |
| 12 | Cerebellum (Parenchymal) | 0 | Yes | No | Orchiectomy only (hospice) |
| 13 | Sellar Region (Parenchymal) | unknown | Yes | Yes | Unknown |
| 14 | T10–11 (Dural) | 3 | Yes | Yes | Hormonal and cytotoxic |
| 15 | Frontotemporal (Dural) | 14 | Yes | Yes | Hormonal and cytotoxic |
| 16 | T6–7 (Dural) | 2 | Yes | Yes | Hormonal and cytotoxic |
| 17 | Frontoparietal (Dural) | 26 | Yes | Yes | Hormonal and cytotoxic |
| 18 | T8–10 (Dural) | 13 | Yes | Yes | Hormonal and cytotoxic |
| 19 | T8 (Dural) | 3 | Yes | Yes | Hormonal, cytotoxic and immunotherapy |
| 20 | T1–4 (Dural) | 6 | Yes | Yes | Hormonal and cytotoxic |
| 21 | Not specified (Dural) | unknown | Unknown | Yes | Unknown |