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. 2020 Jan 1;11(4):849–857. doi: 10.7150/jca.34847

Figure 6.

Figure 6

Sertindole potentiated the apoptotic-induction effects of cisplatin in GC cells. (A) The MKN45 and MGC803 cells were treated with sertindole alone, cisplatin alone or sertindole in combination with cisplatin for 24 h. The cells were collected and stained with PI at 37 °C for 30 min, then measured by flow cytometry. (B) The histogram of cell apoptosis rates. Data are presented as the mean ± SD of three independent experiments. (C) The MKN45 cells were treated with sertindole alone, cisplatin alone or sertindole in combination with cisplatin for 24 h. The cell lysates were then separated by 12% SDS-PAGE electrophoresis, and cell apoptotic- and growth-related proteins expressions were detected by western blot analysis.