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. 2020 Jan 1;11(3):657–667. doi: 10.7150/jca.38350

Figure 4.

Figure 4

Bazedoxifene combined with paclitaxel further inhibited cell invasion of glioblastoma cells. Bazedoxifene: 5 µM; Paclitaxel: 1 µg/ml. (A). 3-D invasion indicated that bazedoxifene combined with paclitaxel further inhibited cell invasion of LN229 and LN18 cells. Left, representative images. Right, statistical analyses. (B). 3-D invasion showed that bazedoxifene combined with paclitaxel further reduced cell invasion of D456 and 1016 cells. Left, representative images. Right, statistical analyses. (C). Western blotting analyses demonstrated that combination of bazedoxifene with paclitaxel decreased expression levels of vimentin, MMP9 and snail but increased expression levels of E-cadherin in LN299 cells. (D) Real time qPCR analyses demonstrated that combination of bazedoxifene with paclitaxel decreased expression levels of vimentin, MMP9 and snail but increased expression levels of E-cadherin in D456 and 1016 cells. *p<0.1; **p<0.01; ***p<0.001