Table 3.
Association of age and LN positivity in China dataset.
| Age, year | N1 vs. N0 | N2 vs. N0 | N3a vs. N0 | N3b vs. N0 | ||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |
| Unadjusted | ||||||||
| T stage T1 | ||||||||
| 18-39 | 1.112(0.481-2.573) | .803 | 3.133(1.419-6.917) | .005 | 3.615(1.307-10.004) | .013 | 5.423(0.887-33.143) | .067 |
| 40-49 | 1.700(0.924-3.126) | .088 | 1.607(0.729-3.543) | .240 | 1.757(0.622-4.964) | .287 | 1.004(0.090-11.19) | .997 |
| 50-59 | 1.114(0.627-1.978) | .713 | 1.262(0.615-2.590) | .525 | 0.278(0.058-1.326) | .108 | 1.114(0.156-7.976) | .915 |
| 60-69 | Reference | Reference | Reference | Reference | ||||
| 70+ | 1.116(0.516-2.414) | .781 | 1.741(0.734-4.131) | .209 | 1.813(0.577-5.701) | .309 | / | / |
| T stage T2 | ||||||||
| 18-39 | 1.752(0.720-4.267) | .217 | 1.188(0.423-3.340) | .743 | 1.627(0.520-5.095) | .403 | 13.667(2.548-73.304) | .002 |
| 40-49 | 0.667(0.304-1.464) | .313 | 0.617(0.265-1.437) | .263 | 0.563(0.192-1.656) | .297 | / | / |
| 50-59 | 0.808(0.421-1.549) | .520 | 1.261(0.674-2.360) | .469 | 1.286(0.600-2.756) | .518 | 1.500(0.244-9.213) | .662 |
| 60-69 | Reference | Reference | Reference | Reference | ||||
| 70+ | 1.364(0.655-2.841) | .407 | 0.578(0.217-1.538) | .273 | 0.792(0.265-2.360) | .675 | / | / |
| T stage T3 | ||||||||
| 18-39 | 1.356(0.587-3.130) | .475 | 1.027(0.442-2.387) | .951 | 2.576(0.172-5.662) | .018 | 4.294(1.647-11.199) | .003 |
| 40-49 | 0.795(0.365-1.732) | .563 | 1.204(0.619-2.343) | .585 | 0.923(0.409-2.083) | .847 | 1.468(0.526-4.099) | .463 |
| 50-59 | 0.820(0.464-1.449) | .494 | 0.741(0.429-1.277) | .280 | 0.908(0.495-1.668) | .757 | 1.379(0.616-3.088) | .435 |
| 60-69 | Reference | Reference | Reference | Reference | ||||
| 70+ | 0.883(0.440-1.769) | .725 | 0.686(0.343-1.372) | .287 | 0.986(0.473-2.058) | .971 | 0.986(0.343-2.838) | .980 |
| T stage T4 | ||||||||
| 18-39 | 1.120(0.696-1.802) | .642 | 1.171(0.726-1.801) | .470 | 1.565(1.037-2.363) | .033 | 2.255(1.439-3.535) | .000 |
| 40-49 | 1.063(0.740-1.527) | .740 | 0.768(0.542-1.089) | .139 | 1.162(0.838-1.612) | .369 | 1.460(1.004-2.122) | .048 |
| 50-59 | 0.979(0.727-1.319) | .891 | 0.867(0.659-1.140) | .306 | 1.100(0.841-1.439) | .486 | 1.171(0.851-1.610) | .333 |
| 60-69 | Reference | Reference | Reference | Reference | ||||
| 70+ | 0.901(0.617-1.317) | .591 | 1.126(0.809-1.566) | .483 | 0.847(0.597-1.203) | .354 | 0.985(0.654-1.484) | .942 |
| Adjusted for covariates* | ||||||||
| T stage T1 | ||||||||
| 18-39 | 1.008(0.427-2.383) | .985 | 3.204(1.395-7.359) | .006 | 3.532(1.199-10.41) | .022 | 12.039(1.365-106.2) | .025 |
| 40-49 | 1.603(0.857-2.999) | .139 | 1.608(0.714-3.623) | .252 | 1.533(0.521-4.509) | .437 | 1.757(0.135-22.80) | .667 |
| 50-59 | 1.086(0.606-1.946) | .781 | 1.239(0.594-2.583) | .568 | 0.252(0.052-1.224) | .087 | 1.441(0.168-12.371) | .739 |
| 60-69 | Reference | Reference | Reference | Reference | ||||
| 70+ | 1.168(0.529-2.580) | .701 | 1.737(0.702-4.301) | .233 | 2.263(0.667-7.683) | .190 | / | / |
| T stage T2 | ||||||||
| 18-39 | 1.829(0.733-4.567) | .196 | 1.078(0.371-3.129) | .890 | 1.453(0.449-4.704) | .533 | 12.616(2.091-76.134) | .006 |
| 40-49 | 0.667(0.297-1.498) | .327 | 0.578(0.240-1.393) | .222 | 0.483(0.159-1.474) | .201 | 0.000E+00 | .998 |
| 50-59 | 0.809(0.418-1.563) | .527 | 1.293(0.675-2.475) | .438 | 1.237(0.562-2.723) | .597 | 1.193(0.182-7.836) | .854 |
| 60-69 | Reference | Reference | Reference | Reference | ||||
| 70+ | 1.311(0.622-2.763) | .477 | 0.534(0.194-1.464) | .223 | 0.703(0.229-2.161) | .539 | 0.000E+00 | .998 |
| T stage T3 | ||||||||
| 18-39 | 1.500(0.618-3.639) | .370 | 1.106(0.454-2.695) | .825 | 2.550(1.083-6.002) | .032 | 3.703(1.299-10.55) | .014 |
| 40-49 | 0.835(0.375-1.861) | .659 | 1.222(0.613-2.436) | .569 | 0.947(0.406-2.210) | .900 | 1.487(0.507-4.360) | .470 |
| 50-59 | 0.916(0.509-1.647) | .769 | 0.756(0.433-1.321) | .326 | 0.877(0.466-1.650) | .684 | 1.227(0.525-2.869) | .637 |
| 60-69 | Reference | Reference | Reference | Reference | ||||
| 70+ | 0.909(0.446-1.851) | .792 | 0.756(0.373-1.533) | .438 | 1.078(0.503-2.311) | .848 | 1.270(0.419-3.850) | .673 |
| T stage T4 | ||||||||
| 18-39 | 1.235(0.760-2.009) | .394 | 1.215(0.783-1.884) | .385 | 1.631(1.066-2.495) | .024 | 2.267(1.393-3.690) | .001 |
| 40-49 | 1.129(0.782-1.629) | .517 | 0.785(0.552-1.117) | .179 | 1.146(0.819-1.601) | .426 | 1.326(0.885-1.988) | .172 |
| 50-59 | 0.999(0.740-1.349) | .994 | 0.870(0.660-1.148) | .325 | 1.080(0.821-1.419) | .583 | 1.160(0.826-1.630) | .392 |
| 60-69 | Reference | Reference | Reference | Reference | ||||
| 70+ | 0.920(0.628-1.349) | .670 | 1.149(0.824-1.603) | .412 | 0.901(0.631-1.287) | .566 | 1.206(0.777-1.872) | .404 |
CI = confidence interval; Ref = referent; OR = odds ratio. *Covariates include log (number of lymph nodes examined), year of diagnosis, differentiation, sex, type of surgery.