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. 2020 Jan 1;11(3):599–609. doi: 10.7150/jca.35041

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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The expression of circ_100395 in ovarian cancer patients and the relationship with patients' clinicopathological parameters. (A) circ_100395 was significantly down-expressed in ovarian cancer tissues than in adjacent normal tissues evaluated by RT-qPCR. (B) The relative circ_100395 expression was down-regulated in 80% (48/60) patients with ovarian cancer revealed as the form of Log2 (T/N). (C) The correlation between the expression of circ_100395 and overall survival times of patients with ovarian cancer. All experiments were repeated at least three time. (D) The correlation between the expression of circ_100395 and FIGO stage. (E) The correlation between circ_100395 expression and lymph node metastasis. (F) The correlation between circ_100395 and distant metastasis. (G) The expression of circ_100395 is down-regulated in ovarian cancer cell lines (SKOV3, A2780, OV2008, IGROV1 and ES-2) compared with that in normal ovarian epithelial normal cell line. *P<0.05, **P<0.01, ***P<0.001.