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. 2020 Jan 1;11(3):599–609. doi: 10.7150/jca.35041

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Overexpression of circ_100395 suppresses the proliferation, migration, invasion and process of epithelial-mesenchymal transition (EMT) in ovarian cancer cells. (A & B) The overexpression efficiency of circ_100395 by a lentivirus-based method in SKOV3 and ES-2 cell lines. (C & D) The effect of up-regulated circ_100395 significantly inhibit the proliferation of SKOV3 and ES-2 cells in vitro using CCK-8 assay. (E & F) The overexpression of circ_100395 significantly reduced the number of migrated cells in SKOV3 and ES-2 cell lines, measured by Transwell assay. (G) After the overexpression of circ_100395, the expression of the epithelial marker, E-cadherin was significantly upregulated, while the mesenchymal markers, N-cadherin and Snail were dramatically downregulated in both SKOV3 and ES-2 cell lines. *** P < 0.001, N.S. means no significant difference.