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p53 might be the key target of circ_100395/miR-1228 axis in ovarian cancer. (A) The predicted 3ʹUTR binding regions miR-1228 on p53. (B) The relative luciferase activity in 293 T cells after co-transfection with pmirGLO-p53-WT or pmirGLO-p53-MUT, along with miR-1228 mimics or miR-1228 NC. (C) The expression level of p53 in circ_100395 or miR-1228 up-regulated ovarian cancer cells. *** P < 0.001
