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VG9-IL-24 induced apoptosis in breast cancer cells via PI3K/β-catenin signaling pathway. (A) MDA-MB-231 cells treated with PBS, VG9-IL-24, VG9-EGFP for 48 h were harvested, lysed and prepared to be available for western blot analysis. Reduced expressions of PI3K, phosphorylation of Akt and GSK-3β, and β-catenin were observed in VG9-IL-24-treated cells. β-actin was used as a loading control. (B) Schematic illustration of VG9-IL-24 regulation of PI3K/β-catenin signaling pathway.
