Table 5.

Cox univariate and multivariate analyses of overall survival among 230 ccRCC patients.

ccRCC patients (n = 230)	Univariate analysis			Multivariate analysis
	HR	95% CI	p value	HR	95% CI	p value
Gender (F/M)	1.058	0.702 - 1.594	0.788	-	-	-
Age (years)	1.044	1.026 - 1.063	< 0.001	1.042	1.023 - 1.061	< 0.001
Tumor Size (cm)	1.092	1.039 - 1.148	0.001	1.016	0.930 - 1.366	0.900
Capsule Invasion (yes/no)	2.886	1.928 - 4.320	< 0.001	1.723	0.865 - 4.168	0.274
Vein Invasion (yes/no)	2.747	1.788 - 4.221	< 0.001	1.700	0.899 - 3.217	0.103
Necrosis (yes/no)	2.010	1.040 - 3.885	0.038	1.153	0.584 - 2.276	0.682
T Stage (T3-T4 vs. T1-T2)	3.070	2.052 - 4.593	< 0.001	1.246	0.790 - 3.016	0.282
N Stage (N1-N2 vs. N0/Nx)	5.112	2.543 - 10.276	< 0.001	2.176	0.989 - 4.786	0.053
M Stage (M1 vs. M0/Mx)	3.886	2.155 - 7.009	< 0.001	1.327	0.478 - 3.686	0.587
Clinical Stage	1.749	1.450 - 2.109	< 0.001	1.537	1.257 - 1.880	< 0.001
Furhman Grade	1.456	1.167 - 1.816	0.001	1.349	1.068 - 1.703	0.012
5hmC (high/low)	0.658	0.430 - 1.009	0.055	0.724	0.462 - 1.133	0.158