Table 6.

Cox univariate and multivariate analyses of cancer specific survival among 230 ccRCC patients.

ccRCC patients (n = 230)	Univariate analysis			Multivariate analysis
	HR	95% CI	p value	HR	95% CI	p value
Gender (F/M)	1.228	0.684 - 2.204	0.493	-	-	-
Age (years)	1.012	0.991 - 1.034	0.269	-	-	-
Tumor Size (cm)	1.142	1.074 - 1.214	< 0.001	1.072	0.895 - 1.455	0.497
Capsule Invasion (yes/no)	4.166	2.377 - 7.302	< 0.001	1.390	0.914 - 4.633	0.146
Vein Invasion (yes/no)	5.811	3.326 - 10.155	< 0.001	2.273	1.187 - 4.351	0.013
Necrosis (yes/no)	1.680	0.665 - 4.247	0.273	-	-	-
T Stage (T3-T4 vs. T1-T2)	5.735	3.086 - 10.658	< 0.001	1.163	0.742 - 3.472	0.876
N Stage (N1-N2 vs. N0/Nx)	7.653	3.544 - 16.525	< 0.001	2.203	0.893 - 5.434	0.086
M Stage (M1 vs. M0/Mx)	6.206	3.153 - 12.216	< 0.001	2.129	0.645 - 7.026	0.215
Clinical Stage	2.464	1.859 - 3.265	< 0.001	1.940	1.385 - 2.718	< 0.001
Furhman Grade	1.601	1.183 - 2.169	0.002	1.661	1.179 - 2.339	0.004
5hmC (high/low)	0.405	0.207 - 0.791	0.008	0.381	0.188 - 0.774	0.008