Table 2.
Stratified analyses of association between identified variants and lung cancer.
| Variables | rs670343 | Phetb | rs9309336 | Phetb | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Case AA/AG/GG | Control AA/AG/GG | Adjusted OR a (95%CI) | Pa | Case CC/CT/TT | Control CC/CT/TT | Adjusted OR a (95%CI) | Pa | |||
| Age, yr | ||||||||||
| ≤60 | 271/571/300 | 446/743/332 | 1.23 (1.10-1.39) | 4.74E-04 | 0.467 | 466/532/144 | 544/749/228 | 0.86 (0.76-0.97) | 1.27E-02 | 0.569 |
| >60 | 327/602/260 | 499/752/305 | 1.16 (1.03-1.30) | 0.014 | 456/552/181 | 552/760/244 | 0.90 (0.80-1.02) | 0.088 | ||
| Sex | ||||||||||
| Females | 151/312/157 | 312/469/210 | 1.27 (1.08-1.50) | 3.72E-03 | 0.368 | 254/278/88 | 363/494/134 | 0.95 (0.80-1.12) | 0.514 | 0.348 |
| Males | 447/861/403 | 633/1026/427 | 1.17 (1.06-1.28) | 1.93E-03 | 668/806/237 | 733/1015/338 | 0.86 (0.78-0.95) | 3.29E-03 | ||
| Smoking | ||||||||||
| Never | 210/409/206 | 529/863/376 | 1.17 (1.03-1.33) | 0.019 | 0.571 | 316/396/113 | 657/859/252 | 0.99 (0.87-1.13) | 0.892 | 0.033 |
| Ever | 388/764/354 | 416/632/261 | 1.23 (1.10-1.36) | 2.09E-04 | 606/688/212 | 439/650/220 | 0.82 (0.73-0.92) | 4.17E-04 | ||
| Histology | ||||||||||
| Squamous cell carcinoma | 229/419/174 | 945/1495/637 | 1.10 (0.97-1.24) | 0.149 | 0.129 | 343/367/112 | 1096/1509/472 | 0.78 (0.68-0.88) | 1.12E-04 | 0.098 |
| Adenocarcinoma | 321/653/330 | 945/1495/637 | 1.25 (1.13-1.38) | 8.00E-06 | 503/610/191 | 1096/1509/472 | 0.93 (0.84-1.03) | 0.143 | ||
| Otherc | 48/101/56 | 945/1495/637 | 1.36 (1.11-1.67) | 3.41E-03 | 76/107/22 | 1096/1509/472 | 0.84 (0.68-1.05) | 0.120 | ||
a Derived from additive model using logistic regression analysis with an adjustment for age, sex, smoking status and PCA. b P for heterogeneity test based on χ2-based Q test.