Table 3.
Univariable and multivariable Cox regression analysis in renal cell cancer from TCGA database.
| Variables | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| HR(95%CI) | p | HR(95%CI) | p | |
| Training set(N=428) | ||||
| Age | 1.02(1.00-1.04) | 0.025 | 1.01(0.99-1.03) | 0.132 |
| 17 gene risk score | 2.68(2.22-3.25) | <0.001 | 2.43(1.98-2.96) | <0.001 |
| Gender | 0.857 | |||
| female | 1 | 0.223 | 1 | |
| male | 1.34(0.84-2.14) | 1.05(0.65-1.69) | ||
| Stage | <0.001 | <0.001 | ||
| I | 1 | 1 | ||
| II | 2.78(1.45-5.31) | 2.45(1.25-4.82) | ||
| III | 5.53(3.45-8.86) | 3.45(2.11-5.65) | ||
| Histological type | 0.184 | |||
| ccRCC | 1 | 1 | 0.019 | |
| pRCC | 1.34(0.87-2.07) | 1.75(1.09-2.80) | ||
| Internal validation set(N=182) | ||||
| Age | 0.99(0.97-1.03) | 0.853 | 1.01(0.98-1.03) | 0.648 |
| 17 gene risk score | 1.82(1.34-2.47) | <0.001 | 1.66(1.19-2.30) | 0.002 |
| Gender | 0.538 | 0.804 | ||
| female | 1 | 1 | ||
| male | 0.78(0.37-1.68) | 0.91(0.42-1.96) | ||
| Stage | 0.002 | 0.031 | ||
| I | 1 | 1 | ||
| II | 0.63(0.14-2.83) | 0.90(0.19-4.09) | ||
| III | 3.30(1.57-6.94) | 2.73(1.25-5.97) | ||
| Histological type | 0.890 | 0.929 | ||
| ccRCC | 1 | 1 | ||
| pRCC | 1.05(0.49-2.25) | 1.04(0.47-2.30) | ||
TCGA: The Cancer Genome Atlas (TCGA) project; ccRCC: clear cell renal cell cancer; pRCC: papillary renal cell cancer.