Table 4.
Univariable and multivariable Cox regression analysis in renal cell cancer from FUSCC database.
| Variables | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| HR(95%CI) | p | HR(95%CI) | p | |
| Training set(N=180) | ||||
| Age | 0.530 | 0.620 | ||
| <60 | 1 | 1 | ||
| ≥60 | 1.28(0.59-2.77) | 1.23(0.54-2.81) | ||
| 17 gene risk score | 1.27(1.11-1.43) | <0.001 | 1.28(1.13-1.43) | <0.001 |
| Gender | 0.738 | 0.627 | ||
| female | 1 | 1 | ||
| male | 1.12(0.48-2.75) | 0.81(0.33-1.96) | ||
| Stage | <0.001 | <0.001 | ||
| I | 1 | 1 | ||
| II | 2.79(0.91-8.61) | 2.38(0.72-7.87) | ||
| III | 7.77(3.31-18.2) | 9.31(3.36-25.78) | ||
| Grade | 0.180 | 0.159 | ||
| I-II | 1 | 1 | ||
| III-IV | 1.72(0.78-3.79) | 0.51(0.19-1.31) | ||
| Histological type | 0.180 | |||
| cRCC | 1 | 1 | 0.355 | |
| pRCC | 1.34(0.87-2.07) | 1.52(0.62-3.65) | ||
| Internal validation set(N=90) | ||||
| Age | 0.06 | 0.199 | ||
| <60 | 1 | 1 | ||
| ≥60 | 3.58(0.95-13.54) | 4.25(0.47-38.7) | ||
| 17 gene risk score | 1.37(1.11-1.69) | <0.001 | 1.65(1.11-2.48) | 0.014 |
| Gender | 0.190 | 0.670 | ||
| female | 1 | 1 | ||
| male | 3.97(0.51-31.28) | 0.54(0.03-8.97) | ||
| Stage | <0.001 | 0.005 | ||
| I | 1 | 1 | ||
| II | 16.55(1.49-182.7) | 48.9(2.63-909.0) | ||
| III | 55.86(6.95-448.9) | 48.9(4.38-546.0) | ||
| Grade | 1.21 | 0.441 | ||
| I-II | 1 | 1 | ||
| III-IV | 2.65(0.77-9.11) | 0.491(0.08-2.99) | ||
| Histological type | 0.890 | |||
| cRCC | 1 | 1 | 0.209 | |
| pRCC | 1.05(0.49-2.25) | 3.86(0.47-31.72) | ||
FUSCC: Fudan University Shanghai Cancer Center; ccRCC: clear cell renal cell cancer; pRCC: papillary renal cell cancer.