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. 2020 Jan 1;11(5):1027–1037. doi: 10.7150/jca.37401

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Knockdown of PRPS2 inhibits xenograft tumor growth in vivo. (A) PRPS2 shRNA effectively blocked its protein expression in PC-3 cells. Cells were stably transfected with scramble (sh-Ctrl) or PRPS2 shRNA (sh-PRPS2). PRPS2 protein levels were normalized to α-Tubulin. (B) Gross observation of xenograft tumor size in NOD/SCID mice. (C and D) Silencing of PRPS2 inhibited the tumor growth, including tumor volume (P < 0.001) and weight (P = 0.028, n = 6). (E) H&E‑stained paraffin‑embedded sections obtained from xenografts of PC-3 cells. (F) Top: Immunohistochemical analysis of Ki-67 in the xenografts; Bottom: The apoptosis in tumor tissues was evaluated by TUNEL assay (×200). Graphical illustrated the quantification of Ki-67 and TUNEL positive cells percentage. ^***P < 0.001.