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. 2020 Jan 1;11(5):1027–1037. doi: 10.7150/jca.37401

Figure 5.

Figure 5

PRPS2 was an androgen-responsive gene. (A) Western blotting of AR protein expression in prostate cancer cell lines and normal prostate epithelial cell lines (RWPE-1). (B) qRT-PCR analysis of PRPS2 expression with androgen-starved for 72 h and treated with DHT 48 h in dose series of 0 nM, 1 nM, 10 nM, 100 nM, 1000 nM in LNCaP. The expression of PRPS2 after DHT stimulation was normalized to the expression without DHT stimulation. (C) The efficiency of siAR on the expression of AR was confirmed by qRT-PCR and the expression of PRPS2 was tested after transfection of siAR compared with NC in LNCaP cells. Data are presented as the mean ± SD (n = 3). (*P < 0.05; **P < 0.01; ***P < 0.001).