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MiR-149-5p alters the MMP9 expression under the co-culture condition via directly target the 3'UTR of MMP9-mRNA. (A) Sequence alignment of the MMP9 3'UTR with wild-type versus mutant potential miR-149-5p targeting sites. (B-C) Luciferase reporter activity after transfection of wild-type or mutant MMP9 3'UTR reporter construct in SK-HEP-1 and HA22T with over expression miR-149-5p of miR-149-5p inhibitor compared to the control cells.
