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An in vivo mouse model proves the role of M2 macrophage-miR149-5p function in HCC progression. (A) SK-HEP-1-cells were transduced with Luciferase and with either pLKO or oemiR-149-5p and then co-injected with either matrigel or THP-1 into left lobe of liver and IVIS imaging was used to determine the tumor growth and metastasis in mice in each group. (B) Quantitative analysis of number of mice with metastasis in each group. *p < 0.05.
