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. 2020 Jan 2;2020:6946037. doi: 10.1155/2020/6946037

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Copyright © 2020 Jianbin Bi et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Irisin mitigates liver injury in old rats after hepatic IR. Partial (70%) liver arterial/portal venous blood was interrupted for 40 minutes in 22-month-old rats. Irisin was administrated in old rats (iv. 250 μg/kg, single dose) at the beginning of reperfusion; Samples were harvested at 24 h after reperfusion. (a–c) Serum TNFα, IL6, and IL10 levels. (d–f) Serum MDA, SOD, and GSH-PX levels. (g–i) Serum lactate, LDH, and ALT levels. (j, k) TUNEL (green) staining of the liver and percentage of TUNEL-positive cells. (l) Liver water content. (m) Percentage of necrotic areas. (n) Liver histological scores. (o) H&E staining of the liver. n = 6; mean ± SEM; ^∗P < 0.05 and ^∗∗P < 0.01.