Figure 3.

TET2 mutations in mucosa-associated lymphoid tissue lymphomas. (A) DNA methylation heatmap constructed using supervised hierarchical Ward clustering of the 2,208 differentially methylated CpG probes between TET2 mutated and TET2 wild-type marginal zone lymphoma (Limma moderated t-test, false discovery rate <0.05) (Online Supplementary Table S3A). (B) Distribution of probes interrogating promoter regions discriminating fully/partially methylated versus unmethylated states (Fisher’s test, P<0.05) in cases bearing or not harboring a specific genetic lesion.