Figure 2.

Clonal mutations detected in study participants. (A) Clonal dynamics for women with two blood samples collected approximately ten years apart. Trios of one case and two controls are shown in each panel. The ages at first and second collection are on the x-axis while the variant allele fraction is on the y-axis. Dots connected by a line represent the same mutation seen in both blood collections. Individual dots represent mutations only seen in a single blood collection. (B) Clonal mutations for individuals with only a single blood collection. Trios of one matched case and two controls are shown in each panel with female trios numbered <100 and male trios numbered >100. The y-axis portrays variant allele fraction and each dot represents a mutation seen in the respective individual.