Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Apr 11;104(12):2418–2428. doi: 10.3324/haematol.2018.208843

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright© 2019 Ferrata Storti Foundation

Material published in Haematologica is covered by copyright. All rights are reserved to the Ferrata Storti Foundation. Use of published material is allowed under the following terms and conditions:

https://creativecommons.org/licenses/by-nc/4.0/legalcode. Copies of published material are allowed for personal or internal use. Sharing published material for non-commercial purposes is subject to the following conditions:

https://creativecommons.org/licenses/by-nc/4.0/legalcode, sect. 3. Reproducing and sharing published material for commercial purposes is not allowed without permission in writing from the publisher.

PMC Copyright notice

Figure 5. — DOCK2 knockdown in transplanted MV4;11 cells enhanced the treatment benefit of ara-C in NSG mice, both alone and in combination with MK8776. (A) Survival of immunodeficient NSG mice transplanted with MV4;11 cells (0.6 × 10⁶ cells) after daily intraperitoneal (i.p.) injections of vehicle, ara-C (50 mg/kg), MK8776 (10 mg/kg), MK1775 (15 mg/kg), ara-C+MK8776, or ara-C+MK1775 for 3 consecutive days. When combined with ara-C, MK8776 and MK1775 were injected 30 min after the ara-C injection. (B) Bone marrow blast percentage was measured 7 days after the start of treatment. The combined treatment with ara-C and MK8776 resulted in significantly reduced bone marrow blast percentage in NSG mice transplanted with DOCK2 KD MV4;11 cells, compared with mice treated with either single agent. *P<0.05; **P<0.01. C: mice transplanted with MV4;11 cells expressing control short hairpin (sh)RNA; KD: mice transplanted with MV4;11 cells expressing shRNA against DOCK2.