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. 2019 Feb 28;104(12):2493–2500. doi: 10.3324/haematol.2018.206250

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Figure 1. — Platelet desialylation in human and murine type 2B von Willebrand disease (vWF) in vivo. (A-B) Analysis of the correlation between RCA binding and the platelet count in patients with type 2B vWD (n=36) (A) (left panel: r²=0.113 (P=0.048) and healthy controls (n=35) (B) r²=0.095 (P=0.092). Distribution of platelet counts (C) and RCA mean fluorescence intensity (MFI) (D) or RCA/MPV (E) values in healthy controls and in patients with type 2B vWD, as a function of the mutation in the vWF A1 domain (p.R1341Q, n=30, p.R1306Q, n=4, p.V1316M, n=2). A one-way ANOVA was followed by Dunnett’s test; *P<0.05. (F-G) Distribution of RCA MFI (F) or RCA/CD41 (G) values in WT (n=61) and 2B mice (n=67) (unpaired Student’s t-test; ***P<0.001).