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. 2020 Jan 14;10:218. doi: 10.1038/s41598-019-57076-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ETV5 is required for cell growth of neuroblastoma cell lines in vivo. (a) In vivo observation of tumour growth of SH-SY5Y cells after ETV5 knockdown (shETV5) compared to control cells (shCtrl). (n_shCtrl = 4; n_shETV5 = 6; mean with error bars represent SD after error propagation). (b) Histological and immunohistochemical analysis of the xenograft tumour sections with H&E and Ki67 (proliferation) staining. (c) Relative Ki67 positive counts (%) for shETV5 xenograft tumours compared to control (shCtrl). (n_shCtrl = 5; n_shETV5 = 6; mean with error bars represent SD after error propagation). (d) Western blot analysis for ETV5 after ETV5 knockdown (shETV5) in SH-SY5Y cells. (cropped images, full-length images are presented in Supplementary Fig. S7c). (e) Relative ETV5 mRNA expression levels of SH-SY5Y xenograft tumour samples after ETV5 knockdown (shETV5) compared to control (shCtrl). (n_shCtrl = 4; n_shETV5 = 5; mean with error bars representing SD after error propagation) (*p < 0.05; **p < 0.01; ***p < 0.001).