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. 2020 Jan 14;10:218. doi: 10.1038/s41598-019-57076-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The ETV5 transcriptional regulatory network controls genes implicated in proliferation. (a) Hierarchical clustering and heat-map representation of common significant differentially expressed genes (112 up; 85 down) after in vitro and in vivo ETV5 knockdown in SH-SY5Y. (b) Gene Set Enrichment Analysis (GSEA) identifies the hallmark genesets “G2M_CHECKPOINT”, “E2F_TARGETS” and “MYC_TARGETS_V1” as significantly enriched among the downregulated genes after shETV5.