Table 2.
Multiple regression analysis of the slope of eGFR decline over one year.
| Glomerular γH2AX | Glomerular 5mC | |||
|---|---|---|---|---|
| Coefficient (95% CI) (per 10% of total glomerulus) | p value | Coefficient (95% CI) (per 10% of total glomerulus) | p value | |
| Model A | −29.35 (−49.68 to −9.02) | p = 0.0068 | −38.73 (−58.59 to −18.86) | P = 0.0005 |
| Model B | −30.78 (−51.72 to −9.84) | P = 0.0060 | −45.41 (−65.58 to −25.24) | P = 0.0001 |
| Model C | −30.33 (−52.28 to −8.37) | P = 0.0091 | −39.48 (−59.41 to −19.55) | P = 0.0005 |
CI: confidence interval. Glomerular γH2AX or 5mC were calculated by total γH2AX or 5mC-positive area/total glomerular area in each patient. Model A: multiple linear regression model for eGFR decline over one year (eGFR 1 year after biopsy- eGFR at biopsy, ml/min/1.73 m2) adjusted by the factors, including age, baseline eGFR and the amount of proteinuria at biopsy. Model B: multiple linear regression model for eGFR decline over one year adjusted by the factors, including age, baseline eGFR, the amount of proteinuria at biopsy, and immunosuppressive therapy after biopsy. Model C: multiple linear regression model for eGFR decline over one year adjusted by the factors, including age, baseline eGFR, the amount of proteinuria at biopsy, and ARB treatment at baseline.