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. 2020 Jan 14;10:207. doi: 10.1038/s41598-019-57052-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pdx1-Cre-directed, constitutively high expression of the tTA and its responder genes to the pancreas. (A) Diagram of a genetically engineered mouse model carrying 3 transgenes (Pdx1-Cre, EF1-LSL-tTA, and TetO-Luciferase) for a temporally and spatially controlled expression of genes in the pancreas. (B,C) In vivo bioluminescence imaging of a Pdx1-Cre EF1-LSL-tTA TetO-Luc transgenic mouse and a littermate control without the EF1-LSL-tTA knockin allele. (D) Luciferase expression in pancreas, liver, and testis. (E,F) Brightfield and GFP images of unfixed pancreas (E) and liver (F) tissues from Pdx1-Cre/CAG-LSL-GFP double transgenic mice; bars represent 5 mm (E) and 50 µm (F).