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. 2020 Jan 14;10:207. doi: 10.1038/s41598-019-57052-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ligand-inducible and Cre-mediated activation of the EF1-tTA and subsequent constitutive expression of TetO-driven responder genes. Schematic of the poly(I:C)-induced activation of the Mx1-Cre transgene that subsequently initiates a constitutive activation of the EF1-LSL-tTA and its responder genes in hematopoietic cells and other tissues. (B) In vivo bioluminescence imaging of Mx1-Cre EF1-LSL-tTA TetO-Luc triple transgenic mice prior to and 14 days after the last injection of poly(I:C). The lower panel shows bioluminescent images of selected organs from a poly(I:C)-treated triple transgenic mouse during necropsy.