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. 2020 Jan 14;11:264. doi: 10.1038/s41467-019-13839-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a FACS analysis of ipsilateral CX3CR1⁺ macrophage expansion in the L4/L5 DRG of WT (n = 6), Adv-Csf1 (n = 7), and CCL2 KO (n = 8) female mice on POD4. b Effect on mechanical thresholds of systemic AP (n = 8) or VEH (n = 10) followed by SNI in female MAFIA mice. c Effect on mechanical thresholds of systemic AP or VEH (n = 5 per group) 4 weeks after SNI in female MAFIA mice. d Effect of CCL2 deletion on mechanical thresholds in male and female mice (n = 5 per group). Gray shading indicates injection days. Data presented as mean ± SEM. One-way ANOVA with Tukey’s correction in a and two-way repeated-measures ANOVA with Sidak’s correction in b–d. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, NS nonsignificant compared with control. Source data are available as a Source Data file.