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. 2019 Oct 23;9(1):1676615. doi: 10.1080/2162402X.2019.1676615

Figure 5.

Figure 5.

Treatment of patient 429–006 with cCD20-BB-ζ CAR T cells.

(a) Cytological specimen from the target malignant lymph node, Wright-Giemsa stain, magnification x100. (b) Copies of integrated CAR gene per μg of PBMC genomic DNA over time relative to infusion, as measured by qPCR. (c) Serum CAMA concentration over time measured by ELISA with mean and SD of well triplicates displayed (lower limit of detection 3.9ng/mL). (d) CD79a and CD20 surface expression among live cells in the patient’s peripheral blood and lymph node over time. (e) Annotated reference canine CD20 sequence (NCBI accession number: XP_005633357) aligned with the CD20 sequences from the patient’s neoplastic B cells pre- and day 162 post-CAR treatment.